LACK OF CORRELATION OF THEILERS VIRUS BINDING TO CELLS WITH INFECTION

The DA strain of Theiler's murine encephalomyelitis virus (TMEV) is a picornavirus which infects the murine central nervous system (CNS). Du ring the acute stage versus the chronic stage, different cell-types ar e infected. To clarify the shift seen during persistent infection, we have screened various cell lines for their ability to support TMEV inf ection and used virus binding assays to determine if there was a corre lation between permissiveness and virus binding. Cell lines of differe nt origins were able to support virus infection to varying degrees. In fectious center assays and viral binding assays demonstrated that perm issiveness to virus infection and the ability of virus to attach to th e cell surface did not always correlate.