Dietary medium-chain triacylglycerol prevents the postprandial rise of plasma triacylglycerols but induces hypercholesterolemia in primary hypertriglyceridemic subjects
L. Asakura et al., Dietary medium-chain triacylglycerol prevents the postprandial rise of plasma triacylglycerols but induces hypercholesterolemia in primary hypertriglyceridemic subjects, AM J CLIN N, 71(3), 2000, pp. 701-705
Background: Previous studies showed divergent results concerning the influe
nce of medium-chain triacylglycerol (MCT) on lipoprotein metabolism.
Objective: The objective of this study was to compare the effects of MCT an
d corn oil on plasma lipids in primary hypertriglyceridemic patients.
Design: Ten subjects ate different proportions of corn oil and MCT for 12 w
k. The subjects first ate a low-fat diet for 2 wk and during the next 4 wk,
corn oil was added as the sole source of fat. Thereafter, for 2-wk periods
, the subjects were sequentially fed corn oil and MCT mixed in the followin
g proportions: 3:1, 1:1, and 0:1. Fasting plasma total cholesterol, triacyl
glycerol, and HDL-cholesterol concentrations were measured at the end of ea
ch period. At the end of the 100%-corn oil and of the 100%-MCT periods, sub
jects were fed a rest meal containing the respective oil (40 g fat/m(2) bod
y surface area) and total cholesterol and triacylglycerols were measured at
2-h intervals over 8 h; fasting lipoprotein composition was also measured.
Results: Compared with corn oil, MCT was associated with a higher mean (+/-
SD) fasting total cholesterol concentration (6.39 +/- 1.14 compared with 5.
51 +/- 0.98 mmol/L, respectively; P < 0.05); non-HDL-cholesterol concentrat
ions were also higher with MCT (5.36 +/- 1.11 mmol/L) than with corn oil (4
.51 +/- 0.92 mmol/L; P < 0.005). In response to the liquid test meal, plasm
a total cholesterol did not change with either diet but triacylglycerols in
creased with the 100%-corn oil diet.
Conclusions: MCT prevents the risk of pancreatitis due to postprandial hype
rtriglyceridemia but has the inconvenience of raising total cholesterol con
centrations in primary hypertriglyceridemic subjects.