Local recurrence following breast conservation therapy in African-Americanwomen with invasive breast cancer

BACKGROUND: African-American women have a lower survival rate than white wo men following a diagnosis of invasive breast cancer. Limited information is available regarding the impact of race on results of breast conservation t herapy (BCT). METHODS: Local recurrence rates were compared in 71 African-American patien ts (73 breasts) and 204 white patients (208 breasts) with stage I and II br east cancer treated with BCT. RESULTS: Overall 5-year actuarial recurrence rates were 13% in African-Amer icans and 4% in whites (P = 0.075), These rates were 9% and 4%, respectivel y, if patients with local skin/soft tissue recurrences were excluded (P = 0 .587). Exclusion of these skin/soft tissue failures eliminated any signific ant difference seen in recurrence between stage II African-American and whi te patients (P = 0.163), African-American women had less favorable recurren ces, including tumor in more than one quadrant or local skin/soft tissue in volvement (P = 0.001), CONCLUSIONS: Overall actuarial recurrence rates were slightly higher, but n ot significantly different, in African-American and white women following B CT, A much less favorable pattern of local recurrence was seen in the Afric an-American patients (P = 0.001), which may represent the presence of more biologically aggressive tumors in these women. (C) 2000 by Excerpta Medica, Inc.