Jyy. Wang et al., A comparison of the effects of desflurane and isoflurane on arterial oxygenation during one-lung ventilation, ANAESTHESIA, 55(2), 2000, pp. 167-173
Citations number
28
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
In a randomised prospective cross-over study, we compared the effects of de
sflurane and isoflurane on arterial oxygenation, heart rate and mean arteri
al pressure during one-lung anaesthesia. Thirty patients scheduled for oeso
phagogastrectomy were randomly assigned to one of two groups. One group of
15 patients received desflurane to an end-tidal concentration of 6% in oxyg
en from induction until the end of 30 min of open chest one-lung ventilatio
n in the lateral position. This was followed by isoflurane to an end-tidal
concentration of 1.1% in oxygen for the next 30 min of one-lung ventilation
. The other group of 15 patients received the two anaesthetic agents in the
reverse order. We found no significant difference in arterial oxygenation,
heart rate or mean arterial pressure between the two inhalational agents.
In the subgroup of 10 patients with pulmonary artery catheters, we found no
significant differences in mixed venous saturation, derived shunt or cardi
ac output. We conclude that during one-lung ventilation, the choice between
desflurane and isoflurane does not significantly influence arterial oxygen
ation.