Rw. Licht et al., THE EFFECT OF CHRONIC LITHIUM TREATMENT ON THE CALIBER OF AXONS AND NERVE-FIBERS IN THE RAT SURAL NERVE, European neuropsychopharmacology, 7(2), 1997, pp. 95-98
Cases of peripheral neuropathy have been reported in humans receiving
lithium therapy. However, no previous studies have addressed the quest
ion of whether chronic lithium treatment causes morphological changes
in the peripheral nervous system in experimental animals. The present
study used stereological methods to determine whether long-term admini
stration of lithium affected the calibre of the axons or of the nerve
fibres in the rat sural nerve. Twenty-two rats were divided into 2 gro
ups and given either no treatment or lithium, with serum levels averag
ing from 0.5 to 0.7 mmol/l. After 30 weeks of treatment, the animals w
ere killed and the sural nerve was isolated at the level of the knee a
nd was removed. The cross-sectional area of axons and of nerve fibres
was estimated by point counting. Compared with the controls, a strong
tendency towards a reduced nerve fibre area in the lithium-treated ani
mals was found, with a between-group difference of 1.79 mu m(2) (P=0.0
6). For the axon area, the difference was 0.73 mu m(2) (P=0.20). (C) 1
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