We investigate the feasibility of detecting high-redshift clusters in absor
ption against background active galactic nuclei (AGNs) with the next genera
tion of X-ray telescopes. The four limiting factors for detecting clusters
in absorption are the sensitivity of the X-ray spectrometers, the abundance
of X-ray-bright AGNs, the absorption equivalent width, and the sky coverin
g factor of the hot gas in clusters. Based on isothermal and polytropic tem
perature profiles for the gas in clusters, we compute the absorption equiva
lent widths of the most abundant heavy elements in clusters with emission-w
eighted temperatures between 1 keV (typical of groups) and 12 keV (typical
of the hottest known clusters). For typical AGN X-ray spectra, we find that
the easiest lines to detect in absorption arise from He-like Si and S and
Fe xx in groups, He-like Fe in 2-10 keV clusters, and H-like Fe in the hott
est clusters. The sky covering factor of the hot gas is then determined as
a function of absorption equivalent width for a nonevolving cluster populat
ion and for evolving cluster populations in an open (Omega = 0.3) and flat
(Omega = 1.0) universe. In an open universe, approximately 5% of the sky is
covered by hot gas with an equivalent width greater than 1 eV for He-like
Fe absorption. In a high-density universe, the corresponding sky covering f
actor is only 1%. Based on the X-ray luminosity function of AGNs, we find t
hat there are several thousand AGNs beyond z = 1 and several hundred AGNs b
eyond z = 2 that are bright enough to produce detectable absorption feature
s in clusters with future X-ray calorimeters. These results show that an ob
serving program of high-redshift, X-ray-bright AGNs will have the added ben
efit of detecting a significant sample of high-redshift clusters. High-reds
hift clusters can easily be missed in X-ray imaging surveys, since their X-
ray surface brightness can be below the X-ray background.