Mechanisms and consequences of replication fork arrest

Authors
Citation
O. Hyrien, Mechanisms and consequences of replication fork arrest, BIOCHIMIE, 82(1), 2000, pp. 5-17
Citations number
99
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHIMIE
ISSN journal
03009084 → ACNP
Volume
82
Issue
1
Year of publication
2000
Pages
5 - 17
Database
ISI
SICI code
0300-9084(200001)82:1<5:MACORF>2.0.ZU;2-F
Abstract
Chromosome replication is not a uniform and continuous process. Replication forks can be slowed down or arrested by DNA secondary structures, specific protein-DNA complexes, specific DNA-RNA hybrids, or interactions between t he replication and transcription machineries. Replication arrest has import ant implications for the topology of replication intermediates and can trig ger homologous and illegitimate recombination. Thus, replication arrest may be a key factor in genome instability. Several examples of these phenomena are reviewed here. (C) 2000 Societe francaise de biochimie et biologie mol eculaire/Editions scientifiques et medicales Elsevier SAS.