Plasma and erythrocyte lipid peroxidation levels in patients with testis tumor after orchiectomy

Plasma and erythrocyte lipid peroxidation levels of 20 patients with histop athologically confirmed testis cancer and 20 healthy control individuals we re studied between November 1995 and June 1997. The group with testis cance r had a mean age of 24.8 +/- 8.2 yr and the control group's mean age was 28 .3 +/- 6.9 yr. Stage distribution of the testis cancer cases were 4 of stag e A, 10 of stage B, and 6 of stage C. Blood samples of the patients were dr awn after orchiectomy and after 12 h fasting before chemotherapy. Mean plas ma and erythrocyte lipid peroxidation levels were detected to be 14.51 +/- 5.30 nmol malondialdehide (MDA)/mL and 9.30 +/- 2.06 nmol MDA/g hemoglobin (Hb), respectively, in the testis cancer group, whereas the healthy control group had mean plasma and erythrocyte lipid peroxidation levels of 10.7 +/ - 1.82 nmol MDA/mL and 6.18 +/- 1.68 nmol MDA/g Hb, respectively. Plasma an d erythrocyte lipid peroxidation values of the testis cancer patients were determined to be statistically significantly higher than that of the health control group (p < 0.001, p < 0.001). No significant correlation was deter mined between plasma, erythrocyte lipid peroxidation levels and tumor marke rs. In conclusion, it can be said that an increase in the lipid peroxidatio n may play a role in the pathogenesis of testis carcinomas in addition to t he other causes.