Citation
Sk. Srivastava et al., Secondary amines as new pharmacophores for macrofilaricidal drug design, BIOORG MED, 10(4), 2000, pp. 313-314
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X
→ ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
313 - 314
Database
ISI
SICI code
0960-894X(20000221)10:4<313:SAANPF>2.0.ZU;2-E
Abstract
Several secondary amines exhibit promising macrofilaricidal response in viv
o through oral route of administration against Acanthocheilonema viteae in
which N-hexylcyclohexylamine (1) shows 100% macrofilaricidal activity while
a tertiary amine such as 9 elicits predominantly microfilaricidal (93%) re
sponse. (C) 2000 Elsevier Science Ltd. All rights reserved.