A vinylogous cephalosporine bearing a dihydroxythiophene moiety as a potent
ial catechol surrogate has been synthesised (I-e-beta). Even if the anti st
aphylococcus spectrum displayed by this compound is of interest, its activi
ty against Pseudomonas species, expected for such a structure, remains disa
ppointing. (C) 2000 Elsevier Science Ltd. All rights reserved.