Synthesis of a dihydroxythiophene analogue of catechosporines

Authors
Dini, C Aszodi, J
Citation
C. Dini et J. Aszodi, Synthesis of a dihydroxythiophene analogue of catechosporines, BIOORG MED, 10(4), 2000, pp. 349-352
Citations number
6
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
349 - 352
Database
ISI
SICI code
0960-894X(20000221)10:4<349:SOADAO>2.0.ZU;2-C
Abstract
A vinylogous cephalosporine bearing a dihydroxythiophene moiety as a potent ial catechol surrogate has been synthesised (I-e-beta). Even if the anti st aphylococcus spectrum displayed by this compound is of interest, its activi ty against Pseudomonas species, expected for such a structure, remains disa ppointing. (C) 2000 Elsevier Science Ltd. All rights reserved.