Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: Synthesis and structure-activity relationship

Authors
Yanagisawa, H Takamura, M Yamada, E Fujita, S Fujiwara, T Yachi, M Isobe, A Hagisawa, Y
Citation
H. Yanagisawa et al., Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: Synthesis and structure-activity relationship, BIOORG MED, 10(4), 2000, pp. 373-375
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
373 - 375
Database
ISI
SICI code
0960-894X(20000221)10:4<373:NOH5AA>2.0.ZU;2-#
Abstract
Grimes having 5-benzyl-2,3-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evalu ated. Biaromatic and methyl groups, attached to the oxime moiety, and the e thylene bridge between oxime and phenoxy groups are favorable to biological activities. (C) 2000 Elsevier Science Ltd. All rights reserved.