The discovery and synthesis of highly potent, A(2a) receptor agonists

Authors
Keeling, SE Albinson, FD Ayres, BE Butchers, PR Chambers, CL Cherry, PC Ellis, F Ewan, GB Gregson, M Knight, J Mills, K Ravenscroft, P Reynolds, LH Sanjar, S Sheehan, MJ
Citation
Se. Keeling et al., The discovery and synthesis of highly potent, A(2a) receptor agonists, BIOORG MED, 10(4), 2000, pp. 403-406
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
4
Year of publication
2000
Pages
403 - 406
Database
ISI
SICI code
0960-894X(20000221)10:4<403:TDASOH>2.0.ZU;2-N
Abstract
A series of N6,2-disubstituted adenosine analogues have been synthesized an d their functional activity measured against A(2a) and A(1) receptors. Exam ples of compounds with both a lipophilic N6-substituent and amino-functiona lized 2-position were highly active at the A(2a) receptor on the human neut rophil. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.