Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11

Granulocyte colony-stimulating factor (G-CSF) can effectively mobilize hema topoietic stem and progenitor cells from bone marrow into blood, thereby al lowing peripheral blood stem cells (PBSCs) to be used for transplantation. The efficiency of PBSC mobilization response to G-CSF is a multigene trait. DBA/2 (high-responder) and C57BL/6 (low-responder) mice were used for a ge netic analysis of G-CSF-induced progenitor release. Significant linkages we re found on chromosome 2 by analyzing segregation distortion among the high responders of 500 backcross mice and on chromosome 11 by using the quantit ative trait locus analysis of 26 strains of BXD recombinant inbred mice. (C ) 2000 by The American Society of Hematology.