Detection of an anti-RhD antibody 2 years after sensitization in a patientwho had undergone an allogeneic BMT

Authors
Gandini, G Franchini, M de Gironcoli, M Vassanelli, A Benedetti, F Turrini, A Benini, F Aprili, G
Citation
G. Gandini et al., Detection of an anti-RhD antibody 2 years after sensitization in a patientwho had undergone an allogeneic BMT, BONE MAR TR, 25(4), 2000, pp. 457-459
Citations number
10
Categorie Soggetti
Hematology,"Medical Research Diagnosis & Treatment
Journal title
BONE MARROW TRANSPLANTATION
ISSN journal
02683369 → ACNP
Volume
25
Issue
4
Year of publication
2000
Pages
457 - 459
Database
ISI
SICI code
0268-3369(200002)25:4<457:DOAAA2>2.0.ZU;2-M
Abstract
We describe an HLA matched bone marrow transplantation with minor ABO incom patibility and RhD mismatch (donor RhD negative and recipient RhD positive) . GVHD appeared on day +96 and therapy with steroid and cyclosporin was sta rted. When GVHD disappeared and immunosuppressive therapy was stopped (2 ye ars after BMT), an anti-RhD antibody was detected in the patient's serum. T he delayed appearance of this antibody may have been associated with the pr olonged immunosuppression that was required for treatment of the patient's GVHD.