Voltammetric determination of azepine and phenothiazine drugs with DNA biosensors

Authors
Vanickova, M Buckova, M Labuda, J
Citation
M. Vanickova et al., Voltammetric determination of azepine and phenothiazine drugs with DNA biosensors, CHEM ANAL, 45(1), 2000, pp. 125-133
Citations number
5
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHEMIA ANALITYCZNA
ISSN journal
00092223 → ACNP
Volume
45
Issue
1
Year of publication
2000
Pages
125 - 133
Database
ISI
SICI code
0009-2223(2000)45:1<125:VDOAAP>2.0.ZU;2-2
Abstract
The preconcentration combined with differential pulse voltammetry was utili zed for the trace determination of six antidepressive drugs at the surface and bulk phase-DNA modified carbon paste electrodes. For accumulation time of 240 s, the detection limits at the level of nmol l(-1) were obtained. Th e bulk phase modified biosensor was stable for a period of 3 months and the sensitivity of determination is comparable with that reported for the pote ntiometric stripping analysis measurement.