Synthesis of optically active N-hydroxylamines by asymmetric hydrogenationof nitrones with iridium catalysts

Authors
Murahashi, SI Tsuji, T Ito, S
Citation
Si. Murahashi et al., Synthesis of optically active N-hydroxylamines by asymmetric hydrogenationof nitrones with iridium catalysts, CHEM COMMUN, (5), 2000, pp. 409-410
Citations number
21
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
5
Year of publication
2000
Pages
409 - 410
Database
ISI
SICI code
1359-7345(2000):5<409:SOOANB>2.0.ZU;2-B
Abstract
Asymmetric hydrogenation of nitrones with the iridium catalyst system, prep ared from [IrCl(cod)](2), (S)-BINAP, and (NBu4BH4)-B-n, gives the correspon ding N-hydroxylamines, which are important as biologically active compounds and precursors of amines, with high enantioselectivity (up to 86% ee).