Derivatised lipids in membranes. Physico-chemical aspects of N-biotinyl phosphatidylethanolamines, N-acyl phosphatidylethanolamines and N-acyl ethanolamines

The physical properties of N-biotinyl phosphatidylethanolamines, N-acyl pho sphatidylethanolamines and of N-acyl ethanolamines, in aqueous dispersions, are reviewed. Emphasis is placed on the calorimetric (i.e. chain melting) properties, the thermotropic phase behaviour, certain aspects of the struct ure and dynamics, and the miscibility with other membrane lipids. In the ca se of N-biotinyl phosphatidylethanolamines, the specific binding of avidin, and in the case of N-acyl ethanolamines, the function of the third chain, is also considered. All of these properties are relevant to the role of the se rather unusual lipids in membranes. (C) 2000 Elsevier Science Ireland Lt d. All rights reserved.