Reduced deformability of erythrocytes as feature of congenital dyserythropoietic anaemia type II (HEMPAS)

Authors
Izzo, P Spagnuolo, A Manicone, A Nazzaro, P Lauta, VM
Citation
P. Izzo et al., Reduced deformability of erythrocytes as feature of congenital dyserythropoietic anaemia type II (HEMPAS), CL HEMORH M, 21(3-4), 1999, pp. 425-430
Citations number
17
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
ISSN journal
13860291 → ACNP
Volume
21
Issue
3-4
Year of publication
1999
Pages
425 - 430
Database
ISI
SICI code
1386-0291(1999)21:3-4<425:RDOEAF>2.0.ZU;2-I
Abstract
In this study we report results regarding erythrocytes deformability in con genital dyserythropoietic anemia type II (HEMPAS) by the use of LORCA (Lase r-assisted Optical Rotational Cell Analyzer). The reduced erythrocytes defo rmability observed in seven case of CDA II is caused by changes in the stru cture of glycoproteins due to the incomplete glycosylation of erythrocytic and erythroblastic membrane. Erythrocytes deformbility (EI) was shown to be inversely related with mean corpuscular volume (MCV) and mean haemoglobin concentration (MCH).