How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

Authors
Mullins, RD
Citation
Rd. Mullins, How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures, CURR OP CEL, 12(1), 2000, pp. 91-96
Citations number
42
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
12
Issue
1
Year of publication
2000
Pages
91 - 96
Database
ISI
SICI code
0955-0674(200002)12:1<91:HWPATA>2.0.ZU;2-K
Abstract
In most cells, the structure of the actin cytoskeleton is regulated by Rho- family G proteins. Recent work has outlined a highly conserved signaling pa thway from G protein activation to actin assembly. The key downstream compo nents are WASP family proteins - adaptor molecules that bind multiple signa ling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functiona l protein complex that nucleates and crosslinks actin filaments.