Complexity in the spindle checkpoint

Authors
Burke, DJ
Citation
Dj. Burke, Complexity in the spindle checkpoint, CUR OP GEN, 10(1), 2000, pp. 26-31
Citations number
37
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X → ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
26 - 31
Database
ISI
SICI code
0959-437X(200002)10:1<26:CITSC>2.0.ZU;2-V
Abstract
Cell viability requires accurate chromosome segregation at mitosis. The spi ndle checkpoint ensures that anaphase is not attempted until the sister chr omatids of each chromosome are attached to spindle microtubules from opposi te poles. The checkpoint mechanism involves a signal transduction cascade t hat is more complex than was originally envisioned.