Citation
H. Laman et al., Viral-encoded cyclins, CUR OP GEN, 10(1), 2000, pp. 70-74
Citations number
50
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X
→ ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
70 - 74
Database
ISI
SICI code
0959-437X(200002)10:1<70:VC>2.0.ZU;2-X
Abstract
D-type cyclin homologs have been found in the genomes of herpesviruses asso
ciated with neoplasias. They appear to exploit features of G(1) cyclins but
extend their properties to allow for deregulation of the cell cycle. Advan
ces in the study of the molecular basis for these novel features as well as
the potential role of viral cyclins in tumorigenesis are addressed.