Citation
Cj. Sherr et Jd. Weber, The ARF/p53 pathway, CUR OP GEN, 10(1), 2000, pp. 94-99
Citations number
49
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN GENETICS & DEVELOPMENT
ISSN journal
0959437X
→ ACNP
Volume
10
Issue
1
Year of publication
2000
Pages
94 - 99
Database
ISI
SICI code
0959-437X(200002)10:1<94:TAP>2.0.ZU;2-Q
Abstract
The ARF tumor suppressor connects pathways regulated by the retinoblastoma
protein and p53, ARF inactivation reduces p53-dependent apoptosis induced b
y oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a nov
el mechanism for preventing p53 turnover and provides a framework for under
standing how stress signals cooperate to regulate p53 function.