S. Frame et A. Balmain, Integration of positive and negative growth signals during ras pathway activation in vivo, CUR OP GEN, 10(1), 2000, pp. 106-113
Expression of RAS proteins can have either positive or negative effects on
cell growth, differentiation and death. New technologies are being develope
d for the generation of animal models to address the questions of where, wh
en and how much Ras is expressed during tumorigenesis, and how these dispar
ate signals are integrated during multistage carcinogenesis.