The many routes of bacterial transfer RNAs after aminoacylation

Subsequent to their aminoacylation, tRNAs are subject to specific maturatio n and/or correction processes. Aminoacylated tRNAs ready for use in transla tion are then specifically channelled to the ribosomal A or P sites. Struct ural and biochemical studies have opened the way towards furthering our und erstanding of these routes to the ribosome, which involve a strict distinct ion between initiator and elongator tRNAs.