Highlights of semi-synthetic developments from erythromycin A

Authors
Wu, YJ
Citation
Yj. Wu, Highlights of semi-synthetic developments from erythromycin A, CUR PHARM D, 6(2), 2000, pp. 181-223
Citations number
104
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CURRENT PHARMACEUTICAL DESIGN
ISSN journal
13816128 → ACNP
Volume
6
Issue
2
Year of publication
2000
Pages
181 - 223
Database
ISI
SICI code
1381-6128(200001)6:2<181:HOSDFE>2.0.ZU;2-6
Abstract
Earlier semi-synthetic studies of erythromycin A culminated in the discover y of two successful second generation macrolide antibiotics, azithromycin a nd clarithromycin, for the treatment of community-acquired bacterial infect ions. More recent structural modifications of erythromycin A have resulted in the discovery of novel ketolide antibiotics and new motilide prokinetic agents. This review is an account of the semi-synthetic developments from e rythromycin A by chemical transformations.