2,4-Dichlorophenoxyacetic acid/partially methylated-beta-Cyclodextrin inclusion complexes

In the present paper the complexation of 2,4-Dichlorophenoxyacetic acid (2, 4-D) and a partially methylated-beta-Cyclodextrin (PM-beta-CD) has been stu died in solution, being determined from the phase solubility diagram an app arent stability constant of 359.0 M-1 for the complex. Solid complexes were also obtained by different processing methods being investigated the inclu sion process by scanning electron microscopy, infrared spectroscopy, differ ential scanning calorimetry, hot stage microscopy and x-ray diffractometry. Dissolution rate studies of the non-complexed and complexed pesticide were carried out. In all the cases the complex formation improved the dissoluti on rate. 2,4-D / PM-beta-CD complexes may find use in pesticide formulation s since they present important advantages.