Atrichia, ichthyosis, follicular hyperkeratosis, chronic candidiasis, keratitis, seizures, mental retardation and inguinal hernia: a severe manifestation of IFAP syndrome?

A boy with congenital atrichia, ichthyosis follicular, keratitis. cutaneous infections and a huge inguinal hernia, but without deafness is reported. W e believe it represents a new case of ii rare X-linked recessive syndrome k nown as ichthyosis follicularis. alopecia, photophobia syndrome (IFAP), The differential diagnosis from keratitis ichthyosis deafness is discussed. Th e cutaneous infections seen in our case suggest the possibility of consider ing a genetic link between these syndromes.