Cyclooxygenase-independent inhibition of smooth muscle cell mitogenesis byibuprofen

Citation
Aa. Weber et al., Cyclooxygenase-independent inhibition of smooth muscle cell mitogenesis byibuprofen, EUR J PHARM, 389(1), 2000, pp. 67-69
Citations number
13
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
389
Issue
1
Year of publication
2000
Pages
67 - 69
Database
ISI
SICI code
0014-2999(20000211)389:1<67:CIOSMC>2.0.ZU;2-E
Abstract
The aryl-propionic acid derivative, ketoprofen, has been shown to inhibit f ibroblast growth by a cylooxygenase-dependent mechanism [Sanchez, T., Moren o, J.J., 1999. S(+) enantiomer inhibits prostaglandin production and cell g rowth in 3T6 fibroblast cultures. Eur. J. Pharmacol. 370, 63-67]. The prese nt study demonstrates that ibuprofen, another aryl-propionic acid derivativ e, inhibited platelet-derived growth factor-BB (20 ng/ml)-induced mitogenes is of cultured bovine coronary artery smooth muscle cells in a stereo-indep endent manner. In addition, pretreatment of the cells with indomethacin (3 mu M) did not affect the inhibitory effects of ibuprofen enantiomers on smo oth muscle cell mitogenesis. Thus, aryl-propionic acid-type cyclooxygenase inhibitors can inhibit cell proliferation by both, cyclooxygenase-dependent and -independent ways. (C) 2000 Elsevier Science B.V. All rights reserved.