Relative abundance of placental pro-atrial natriuretic factor mRNA in normal pregnancy and pre-eclampsia

Citation
Nm. Gude et al., Relative abundance of placental pro-atrial natriuretic factor mRNA in normal pregnancy and pre-eclampsia, GYNECOL OBS, 49(2), 2000, pp. 114-118
Citations number
18
Categorie Soggetti
da verificare
Journal title
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
ISSN journal
03787346 → ACNP
Volume
49
Issue
2
Year of publication
2000
Pages
114 - 118
Database
ISI
SICI code
0378-7346(2000)49:2<114:RAOPPN>2.0.ZU;2-X
Abstract
Atrial natriuretic factor (ANF), produced by cytotrophoblast cells of the h uman placenta, may be involved in the regulation of uteroplacental blood fl ow, Pre-eclampsia is associated with maternal hypertension and reduced uter oplacental perfusion. The relationship between preeclampsia and placental p roduction of ANF is not known. This study measured pro-ANF mRNA levels by N orthern blot analysis in placentae delivered by caesarean section at preter m and term gestations from women with normotensive and pre-eclamptic pregna ncies and found no significant difference between pre-eclampsia and normal pregnancy at either gestation. This result suggests that placental producti on of ANF is not altered at the pretranslational level during pre-eclampsia , Copyright (C) 2000 S. Karger AG, Basel.