Nm. Gude et al., Relative abundance of placental pro-atrial natriuretic factor mRNA in normal pregnancy and pre-eclampsia, GYNECOL OBS, 49(2), 2000, pp. 114-118
Atrial natriuretic factor (ANF), produced by cytotrophoblast cells of the h
uman placenta, may be involved in the regulation of uteroplacental blood fl
ow, Pre-eclampsia is associated with maternal hypertension and reduced uter
oplacental perfusion. The relationship between preeclampsia and placental p
roduction of ANF is not known. This study measured pro-ANF mRNA levels by N
orthern blot analysis in placentae delivered by caesarean section at preter
m and term gestations from women with normotensive and pre-eclamptic pregna
ncies and found no significant difference between pre-eclampsia and normal
pregnancy at either gestation. This result suggests that placental producti
on of ANF is not altered at the pretranslational level during pre-eclampsia
, Copyright (C) 2000 S. Karger AG, Basel.