Perceived stress and depressive symptoms were examined as correlates and pr
edictors of smoking cessation during pregnancy in a sample of 819 pregnant
smokers (454 baseline smokers and 365 baseline quitters). Women who quit ea
rly in pregnancy had lower levels of stress and depressive symptoms than ba
seline smokers. Adjusting for level of addiction and other demographic fact
ors related to stress and depressive symptoms eliminated the significant as
sociation between depressive symptoms and smoking cessation. Lower levels o
f stress and depressive symptoms were not predictive of cessation in later
pregnancy. Prenatal healthcare providers should continue to assess level of
addiction and provide targeted intensive cessation interventions. Interven
tions that reduce stress and depression may also be of benefit to women who
are continuing smokers in early pregnancy.