Transformations of (S)-1-acyl-3-[(E)-(dimethylamino)-methylidene]-5-(methoxycarbonyl)pyrrolidin-2-ones. A one-step synthesis of (S)-N-benzoyl-3-(1-heteroaryl-5-hydroxy-1H-pyrazolyl-4)alanine esters

Authors
Skof, M Svete, J Stanovnik, B
Citation
M. Skof et al., Transformations of (S)-1-acyl-3-[(E)-(dimethylamino)-methylidene]-5-(methoxycarbonyl)pyrrolidin-2-ones. A one-step synthesis of (S)-N-benzoyl-3-(1-heteroaryl-5-hydroxy-1H-pyrazolyl-4)alanine esters, HETEROCYCLE, 53(2), 2000, pp. 339
Citations number
32
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
2
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000201)53:2<339:TO(>2.0.ZU;2-8
Abstract
(S)-1-Benzoyl-3-[(E)-(dimethylamino)methylide]-5-(methoxycarbonyl)pyrrolidi n- 2-one (1) and (S)-1 -tert-butoxycarbonyl-3-[(E)-(dimethylamino)methylide ne]-5-(methoxycarbonyl)pyrrolidin-2-one (2) were transformed in one step wi th various hydrazines (3-10) into the corresponding (S)-3-(1-substituted 5- hydroxy-1H-pyrazolyl-4)alanine methyl esters (11-19).