Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs

Authors
Tanji, S Aoyagi, H Tabira, H Sato, I Soai, K
Citation
S. Tanji et al., Catalytic asymmetric synthesis of chiral 4-pyrazolylalkanols by the enantioselective alkylation of pyrazole-4-carbaldehydes with dialkylzincs, HETEROCYCLE, 53(2), 2000, pp. 381
Citations number
17
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
53
Issue
2
Year of publication
2000
Database
ISI
SICI code
0385-5414(20000201)53:2<381:CASOC4>2.0.ZU;2-4
Abstract
(1 (S) under bar, 2 (R) under bar)-(N) under bar,(N) under bar-Dialkylnorep hedrines catalyze the enantioselective alkylation of various pyrazole-4-car baldehydes with dialkylzincs. Enantiomerically enriched secondary-4-pyrazol ylalkanols with up to 95% e.e. were obtained.