HLA-DMA allele polymorphism: No impact on kidney allograft outcome

The purpose of this study was to analyze the association of HLA-DMA alleles with rejection episodes and early graft loss (EGL) in renal transplant rec ipients. One hundred and eighty four HLA-DMA alleles were retrospectively a nalyzed by DNA sequence analysis in 92 kidney transplant recipients. The ge ne frequencies of HLA-DMA *0101, *0102, *0101 and *0104 were found to be si milar in all recipients, regardless of rejection vs non rejection episodes and EGL incidence. In conclusion, HLA-DMA allele polymorphism did nor: impa ct. renal allograft outcome. (C) American Society for Histocompatibility an d Immunogenetics, 2000. Published by Elsevier Science Inc.