A 4-year-old white boy without a significant family history had morning sti
ffness and painful swelling of his left knee and ankle, right elbow, and do
rsolumbar region of 2 months' evolution. The following laboratory studies w
ere within normal limits: complete blood cell count, C-reactive protein (CR
P), latex, antistreptolysin, and antinuclear antibodies. Rheumatoid factor
was negative and an increase in the erythrocyte sedimentation rate (ESR) wa
s detected (56 mm/h). The pediatric department made an initial diagnosis of
juvenile rheumatoid arthritis, and treatment with acetylsalicylic acid at
100 mg/kg/day and naproxen at 10 mg/kg/day was started. A thick, yellowish
toenail was diagnosed as onychomycosis. No mycologic investigations were pe
rformed.
Intermittent episodes of painful arthritis of different joints were present
. The radiographic features of the peripheral joints included: narrow joint
spaces, articular erosions, soft tissue swelling, and diffuse bony deminer
alization. Characteristic bilateral sacroiliitis and a swollen tendon sheat
h on the left ankle were detected.
At 11 years of age the nail changes had extended to five other toenails and
to four fingernails, were yellow-brown in color, and showed marked subungu
al hyperkeratosis (Figs 1, 2). The rest of the nails showed significant nai
l pitting. Trials of griseofulvin alternated with itraconazole in an irregu
lar form for five consecutive years resulted in no clinical improvement, wh
ich prompted a consultation to our dermatology department. On three differe
nt occasions, KOH nail specimens were negative for fungus, but the presence
of parakeratotic cells aroused the suspicion of psoriasis. A complete phys
ical examination was negative for psoriatic skin lesions. A nail bed biopsy
specimen was characteristic of nail psoriasis (Fig. 3).
The following human leukocyte antigens (HLAs) were positive: A9, A10, B12,
B27, Cw1, Bw4, DR6, DR7, DQ1, DQ2, and DR53.
A diagnosis of juvenile psoriatic arthritis associated with nail psoriasis
was made. Toenail involvement became so painful that walking became very di
fficult. Occlusive 40% urea in vaseline applied to the affected toenails fo
r 48 h resulted in significant improvement.
Currently, the patient is 20 years old with nail involvement, but no psoria
tic skin lesions have ever been observed.