Hemorrhagic and serological complications of Glanzmann's thrombasthenia: Acase report

We present an eight-year-old patient with Glanzmann's thrombasthenia who wa s hospitalized in the Department of Pediatric Hematology and Oncology due t o severe posthemorrhagic anemia caused by massive gingival bleeding and epi staxis in the course of pneumonia. Multiple hemorrhages to the vitreous bod y of both eyeballs occurred during hospitalization. The girl was treated wi th repeated transfusions of a platelet concentrate and thereafter by inject ions of anti-D immunoglobulin into the vitreous body because of lack of res orption of blood from the vitreous bodies. Due to multiple transfusions of platelets and red blood cell concentrates the patient produced specific ant ierythrocyte alloantibodies and lymphocytotoxic antibodies. This complicate d treatment because it was necessary to use blood preparations from phenoty pically compatible donors.