J. Zawadzki, MECHANISM OF HYPOURICEMIA IN A CHILD WITH THE NORMOTENSIVE FORM OF GORDONS-SYNDROME, Kidney & blood pressure research, 20(1), 1997, pp. 64-70
The mechanism of renal tubular urate transport disorder was studied by
the pyrazinamide and probenecid tests in a 12-year-old hypouricemic b
oy suffering from the normotensive form of Gordon's syndrome, with inc
reased distal tubular reabsorption of NaCl (confirmed by the hypotonic
saline diuresis test). The aim of the study was to determine the impa
ct of oral hydration during the tests on the phases of renal tubular u
rate transport: before (I), and during long-term hydrochlorothiazide t
herapy (0.5 mg/kg BW/day) (II), In both periods (I, II), presecretory
reabsorption of urate was within normal limits, Hypouricemia in our pa
tient was caused by decreased postsecretory reabsorption, with or with
out simultaneous increase of tubular urate secretion. The degree of ov
erhydration determines which of these mechanisms is responsible for in
creased renal urate clearance.