Antioxidative and anti-glycation activity of garcinol from Garcinia indicafruit rind

Garcinol, a polyisoprenylated benzophenone derivative, was purified from Ga rcinia indica fruit rind, and its antioxidative activity, chelating activit y, free radical scavenging activity, and anti-glycation activity were studi ed. Garcinol exhibited moderate antioxidative activity in the micellar lino leic acid peroxidation system and also exhibited chelating activity at almo st the same level as citrate. It also showed nearly 3 times greater DPPH (1 ,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alph a-tocopherol by weight in aqueous ethanol solution. In a phenazine methosul fate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum alb umin/fructose system. Thus, garcinol might be beneficial as a potent antiox idant and a glycation inhibitor under specified conditions.