Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin

Authors
Fang, AQ Wong, GK Demain, AL
Citation
Aq. Fang et al., Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin, J ANTIBIOT, 53(2), 2000, pp. 158-162
Citations number
21
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
2
Year of publication
2000
Pages
158 - 162
Database
ISI
SICI code
0021-8820(200002)53:2<158:EOTAAO>2.0.ZU;2-2
Abstract
Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and n igericin. Although elaiophylin has no activity against Candida albicans ATC C 11651, it markedly enhances rapamycin's antifungal activity. Nigericin ha s only weak activity on its own but it also enhances rapamycin action. Surp risingly, elaiophylin does not enhance nigericin activity on C. albicans.