Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp NA-148 II. Physico-chemical properties and structure elucidation

Authors
Takahashi, S Nakano, T Koiwa, T Noshita, T Funayama, S Koshino, H Nakagawa, A
Citation
S. Takahashi et al., Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp NA-148 II. Physico-chemical properties and structure elucidation, J ANTIBIOT, 53(2), 2000, pp. 163-170
Citations number
9
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
2
Year of publication
2000
Pages
163 - 170
Database
ISI
SICI code
0021-8820(200002)53:2<163:AAABNI>2.0.ZU;2-Y
Abstract
Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell ad hesion molecule isolated from the fermentation broth of Streptomyces sp. NA -148. The molecular formula of adxanthromycins A and B were determined as C 42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, a nd the structures of both compounds were elucidated to be a dimeric anthron e peroxide skeleton containing alpha-D-galactose by various NMR spectral an alyses and chemical degradation.