Penetration of cefpirome into the anterior chamber of the human eye after intravenous application

The penetration of intravenously administered cefpirome into the anterior c hamber of the noninflamed human eye was investigated in this study. A total of 42 patients, all hospitalized for cataract extraction, received a dosag e of 1 g or 2 g of cefpirome by iv infusion 1, 2 or 6 h preoperatively. An aqueous humour sample was collected immediately after paracentesis and a bl ood specimen was simultaneously obtained from each patient. All samples wer e analysed for cefpirome concentrations using high-pressure liquid chromato graphy. Mean aqueous humour levels of cefpirome in patients receiving a dos age of 1 g were 1.33 mg/L (1 h), 1.67 mg/L (2 h) and 1.29 mg/L (6 h after a pplication), respectively. When patients received a dosage of 2 g cefpirome the resulting mean aqueous humour concentrations were 1.60 mg/L (1 h), 2.2 7 mg/L (2 h) and 2.39 mg/L (6 h after application), respectively. A statist ically significant difference in aqueous humour concentrations between pati ents receiving 1 g or 2 g of cefpirome could not be proven. In conclusion, cefpirome penetrates well into the anterior chamber of the noninflamed huma n eye in concentrations that are therapeutic for many Gram-positive and Gra mnegative organisms, frequently responsible for anterior segment eye infect ions.