Anticandidal activity of SPA-S-843, a new polyenic drug

Citation
V. Strippoli et al., Anticandidal activity of SPA-S-843, a new polyenic drug, J ANTIMICRO, 45(2), 2000, pp. 235-237
Citations number
6
Categorie Soggetti
Pharmacology,Microbiology
Journal title
Journal of antimicrobial chemotherapy
ISSN journal
03057453 → ACNP
Volume
45
Issue
2
Year of publication
2000
Pages
235 - 237
Database
ISI
SICI code
Abstract
The activity of a new, soluble and stable polyene (SPA-S-843) against Candi da albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lo wer MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida so, conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).