Stability-indicating high-performance liquid chromatographic assay and analysis of decomposition products of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propanoic acid

Authors
Cheung, AP Struble, E Nguyen, N Liu, P
Citation
Ap. Cheung et al., Stability-indicating high-performance liquid chromatographic assay and analysis of decomposition products of 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propanoic acid, J CHROMAT A, 870(1-2), 2000, pp. 179-188
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF CHROMATOGRAPHY A → ACNP
Volume
870
Issue
1-2
Year of publication
2000
Pages
179 - 188
Database
ISI
SICI code
Abstract
A stability-indicating HPLC assay has been developed for 2-{4-[(7-chloro-2- quinoxalinyl)oxy]phenoxy}propanic acid (XK469). XK-469 is the 7-chloro anal og of herbicide Quizalofop and is currently under development as an antineo plastic agent. HPLC separation of XK469 is achieved with an ODS column usin g isocratic elution of an aqueous MeOH mobile phase. The assay is reproduci ble (RSD = 0.9%), linear (r(2) = 0.999), accurate (error = 1.2%) and sensit ive (LDL = 1.2 ng). The HPLC separates XK469 from its forced decomposition products. Identities of the decomposition products have been elucidated. (C ) 2000 Elsevier Science B.V. All rights reserved.