Acute encephalopathy due to aluminum toxicity successfully treated by combined intravenous deferoxamine and hemodialysis

Acute aluminum intoxication is uncommon in clinical practice but can be fat al. This limited experience is reflected in the paucity of data assessing a viable approach to the treatment of these patients. In this report, the au thors describe the clinical course and successful, pharmacokinetic-based de feroxamine-hemodialysis treatment regimen of a patient with severe aluminum encephalopathy following alum bladder irrigation. The combined use of defe roxamine and appropriately timed hemodialysis appears to be a very reasonab le means of treating patients with severe acute aluminum intoxication.