The effects of interferon on the expression of human papillomavirus oncogenes

Citation
Ky. Kim et al., The effects of interferon on the expression of human papillomavirus oncogenes, J GEN VIROL, 81, 2000, pp. 695-700
Citations number
27
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF GENERAL VIROLOGY
ISSN journal
00221317 → ACNP
Volume
81
Year of publication
2000
Part
3
Pages
695 - 700
Database
ISI
SICI code
0022-1317(200003)81:<695:TEOIOT>2.0.ZU;2-3
Abstract
The effects of interferon (IFN)-alpha, IFN-beta and IFN-gamma on human papi llomavirus (HPV) oncogene expression were studied in various cervical carci noma cell lines containing integrated copies of either HPV type 16 or HPV t ype 18. The levels of E6 and E7 transcripts were examined 6 h and 30 h afte r treatment with IFN. In HeLa cells, all three classes of IFNs effected a d ecrease in the level of HPV-18 E6 and E7 transcripts. On the other hand, no ne of the IFNs altered the level of these transcripts in C-4II cells. Only IFN-gamma decreased the level of HPV-16 E6 and E7 transcripts in CaSki and HPK1A cells, while IFN-gamma actually increased the level of these transcri pts in SiHa cells. This differential IFN regulation of HPV expression in va rious cervical cancer cell lines may account for the contradictory clinical results observed after treatment of cervical cancer with IFN.