H. Osada et al., The effect of hyaluronic acid-carboxymethylcellulose in reducing adhesion reformation in rabbits, J INT MED R, 27(6), 1999, pp. 292-296
Citations number
19
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
The effect of hyaluronic acid-carboxymethylcellulose film (Seprafilm(R))* i
n reducing postoperative adhesion formation was examined in a rabbit induce
d-adhesion model. During laparotomy, the ileocaecal region was mechanically
and chemically abraded to induce lesions. After a 28-day recovery period,
adhesions were lysed by microsurgery and Seprafilm(R) was applied to the ly
sed lesion in 10 rabbits and six rabbits received physiological saline. A t
hird laparotomy was performed 10 - 14 days later and the area of adhesion r
eformation was compared to that found prior to application of test material
s. The area of adhesion reformation with Seprafilm(R) decreased to (mean +/
- standard deviation) 11.71 +/- 10.97% of the originally lysed lesion and,
the area was significantly reduced compared with controls treated with phys
iological saline, These results suggest that the use of Seprafilm(R) may be
a valuable new anti-adhesion material for abdominal or pelvic surgery and
may be superior to existing anti-adhesion materials and techniques.