We evaluated the effectiveness of Cutting Balloon angioplasty for ostial le
sions of the left anterior descending artery compared with conventional bal
loon angioplasty. Cutting Balloon angioplasty (n = 7) produced larger acute
gain (1.70 +/- 0.37 vs 0.48 +/- 0.25 mm, P < 0.001) and smaller late loss
index (0.54 +/- 0.55 vs 1.32 +/- 0.81, P < 0.05) than conventional balloon
angioplasty (n = 7). As a result, late restenosis was seen in only two pati
ents undergoing Cutting Balloon angioplasty, but in all seven patients unde
rgoing conventional balloon angioplasty. Ostial lesions of the left anterio
r descending artery may be one of the suitable targets of Cutting Balloon a
ngioplasty.