Ha. Razek et al., It fits! (Intelligence transfer: From images to solutions) massive abdominal ecchymosis and hematoma due to local injection of enoxaparin, J INTERV CA, 13(1), 2000, pp. 71-72
A 67-year-old female was admitted to the hospital with chest pain and short
ness of air. One month previously, she had sustained an anterior myocardial
infarction complicated by the development of a left ventricular aneurysm.
She was taking warfarin at the time of admission and the International Norm
alized Ratio (INR) was 1.8. She was in congestive heart failure thought sec
ondary to unstable angina pectoris and was given weight-adjusted subcutaneo
us enoxaparin injected subcutaneously in the abdominal area. The following
morning she had a massive abdominal hematoma (Fig. 1). With only two doses
of enoxaparin, the INR went to 30.3 and the hematocrit fell from 36.5% to 2
6.2%, requiring transfusion with fresh frozen plasma and packed red blood c
ells. The bleeding time and hematocrit stabilized. She was discharged 5 day
s after admission.