A common polymorphism of the wild type p53 is known at codon 72 of exon 4,
with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53P
ro), A recent study suggested that this polymorphism affects the susceptibi
lity of p53 protein to human papillomavirus E6 oncoprotein mediated degrada
tion and that individuals homozygous for p53Arg are seven times more suscep
tible to HPV-associated carcinogenesis of the cervix than heterozygotes. To
examine whether the p53Arg genotype could be a risk factor for HPV-associa
ted cervical carcinomas in the Korean population, we analyzed the p53 codon
72 polymorphism status of HPV-positive invasive cervical carcinomas from 5
2 Korean women and 103 healthy control samples. The proportion of individua
ls homozygous for p53Arg, homozygous for p53Pro, and heterozygous for the t
wo alleles were 40%, 19%, and 41% in normal healthy controls; 42%, 17%, and
40% in women with HPV-positive invasive cervical carcinoma. There were no
significant differences in the distribution of p53 genotypes between contro
ls and cervical carcinomas. This finding indicates that the p53Arg genotype
is not associated with an increased susceptibility to cervical carcinoma i
n Korean women.