Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact

Authors
Chansakaow, S Ishikawa, T Seki, H Sekine, K Okada, M Chaichantipyuth, C
Citation
S. Chansakaow et al., Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact, J NAT PROD, 63(2), 2000, pp. 173-175
Citations number
13
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
63
Issue
2
Year of publication
2000
Pages
173 - 175
Database
ISI
SICI code
0163-3864(200002)63:2<173:IODATA>2.0.ZU;2-J
Abstract
Miroestrol (1) has been isolated previously as an active principle from "Kw ao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. R einvestigation using bioassay-guided purification has resulted in the isola tion of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.