Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species

Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngb ya majuscula and Schizothrix sp. assemblage collected at Yanuca Island, Fij i. The structures of compounds 1 and 2 were determined by spectroscopic met hods. Both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic aci d, which has previously been described only as a component of kulolide-1 (3 ) and kulokainalide-1 (4), metabolites from the marine mollusk Philinopsis speciosa. Thus, the isolation of the yanucamides from this cyanobacterial a ssemblage supports the hypothesis that the kulolides and related metabolite s are of cyanobacterial origin.